Identification of novel activity against Borrelia burgdorferi persisters using an FDA approved drug library. Although not meant to indicate what would work in people, in vitro experimental testing of drug combinations may give some insight into potential avenues to explore in clinical studies especially regarding late Lyme arthritis.Ī Drug Combination Screen Identifies Drugs Active against Amoxicillin-Induced Round Bodies of In Vitro Borrelia burgdorferi Persisters from an FDA Drug Library. Feng J, Shi W, Zhang S, Sullivan D, Auwaerter PG, Zhang Y. Front Microbiol. Although there is no convincing data that bacteria persist after appropriate treatment in human infection, the idea that bacteria may not be entirely eradicated is a potential explanation. Many hypotheses exist including immunological, neurological, mitochondrial or hormonal. Why some patients fail to improve after antibiotic therapy for Lyme disease is unclear. Lyme borreliosis (Lyme disease): molecular and cellular pathobiology and prospects for prevention, diagnosis and treatment. Coulter P, Lema C, Flayhart D, Linhardt AS, Aucott JN, Auwaerter PG, Dumler JS. Two year evaluation of Borrelia burgdorferi culture and supplemental tests for definitive diagnosis of Lyme disease. Point: antibiotic therapy is not the answer for patients with persisting symptoms attributable to lyme disease. Auwaerter PG, Bakken JS, Dattwyler RJ, Dumler JS, Halperin JJ, McSweegan E, Nadelman RB, O’Connell S, Shapiro ED, Sood SK, Steere AC, Weinstein A, Wormser GP. PMID: 22971779Īntiscience and ethical concerns associated with advocacy of Lyme disease. Misdiagnosis of late-onset Lyme arthritis by inappropriate use of Borrelia burgdorferi immunoblot testing with synovial fluid. PMID: 25090401Ī systematic review of Borrelia burgdorferi morphologic variants does not support a role in chronic Lyme disease. Lyme disease: authentic imitator or wishful imitation? Melia MT, Lantos PM, Auwaerter PG. Unorthodox alternative therapies marketed to treat Lyme disease. Lantos PM, Shapiro ED, Auwaerter PG, Baker PJ, Halperin JJ, McSweegan E, Wormser GP. PMID: 25999231Įditorial commentary: life after Lyme disease. Lyme disease: knowing good evidence to help inform practice. Lantos PM, Branda JA, Boggan JC, Chudgar SM, Wilson EA, Ruffin F, Fowler V, Auwaerter PG, Nigrovic LE. Poor Positive Predictive Value of Lyme Disease Serologic Testing in an Area of Low Disease Incidence. Time for a different approach to Lyme disease and long-term symptoms. Wormser GP, Strle F, Shapiro ED, Dattwyler RJ, Auwaerter PG. PMID: 27931077Ī critical appraisal of the mild axonal peripheral neuropathy of late neurologic Lyme disease. Cadavid D, Auwaerter PG, Rumbaugh J, Gelderblom H. of Atlanta, GA.Īntibiotics for the neurological complications of Lyme disease. This research study is sponsored by MicroB-plex, Inc. The Fisher Center is participating in a clinical research study that may lead to the development of a new diagnostic test for early Lyme disease that may also have implications as corresponding with microbiological cure of the infection. Therefore, accurate, early-stage diagnosis would as current FDA-approved testing for Borrelia burgdorferi is least accurate in the first week or two after acquiring the infection. Overdiagnosis of Lyme disease may lead to unintended consequences such as vascular catheter complications or bacterial superinfections such as C. If not accurately diagnosed and treated, Lyme disease infection may progress to affect the cardiac, neurological, and musculoskeletal systems. PMID: 26550580 Lyme Disease Clinical Management
Lantos PM, Nigrovic LE, Auwaerter PG, Fowler VG Jr, Ruffin F, Brinkerhoff RJ, Reber J, Williams C, Broyhill J, Pan WK, Gaines DN. Open Forum Infect Dis. Geographic Expansion of Lyme Disease in the Southeastern United States, 2000-2014. Lantos PM, Tsao J, Nigrovic LE, Auwaerter PG, Fowler VG, Ruffin F, Foster E, Hickling G. Geographic Expansion of Lyme Disease in Michigan, 2000-2014. Using reported case data helps clinicians anticipate areas of the country previously without Lyme disease who are at risk for what would be an emerging infectious disease in their communities. Lyme disease has been spreading with speed in parts of the South and the Midwest United States. Data will help gain an understanding of reasons why referrals are sought, clinical diagnoses and how both diagnostic and therapeutic decisions are formed. Our researchers have undertaken a comprehensive, retrospective analysis of persons referred for Lyme disease to the Johns Hopkins Infectious Diseases clinic. The following are a selection of our research efforts. The Sherrilyn and Ken Fisher Center for Environmental Infectious Diseases is actively researching tick borne diseases.
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